Miscarriage/Recurrent Pregnancy Loss

Dawn Davenport


Miscarriage/Recurrent Pregnancy Loss

Much is still unknown about miscarriages and recurrent pregnancy loss.

I have always been amazed at what we don’t know about the causes and treatments of miscarriages.  It is such a common occurrence and yet remains a bit of a medical mystery.  Recurrent pregnancy loss is devastating to the couples involved and hearing that the cause or the preferred treatment is simply not known is beyond frustrating.  Doctors tell me that patients often demand action (“Do something, anything, don’t just stand there!”), but medical history is full of stories of unsuccessful and sometimes harmful “treatments”.  Think of the DES debacle of the 1940s through 1960s, where an estimated 5-10 million pregnant women were given this drug that not only was not effective at preventing miscarriage, but was later found to cause cancer and infertility in the daughter exposed inter-utero.  Sometimes nothing is better than something, but the hope is that medical science will learn more about the causes and treatment of recurrent miscarriages.  I was anxious to hear about some of the latest research when I attended the European Infertility Conference (ESHRE).

We did a recent show on Miscarriage/Recurrent Pregnancy Loss and one of the questions we received was whether to take aspirin to prevent miscarriage.  The attitude of the questioner was that basically nothing else was working, so what do I have to lose.  Some recent research addressed this question.  One well designed study in The Netherlands followed 364 women with unexplained recurrent miscarriage.  This was a randomized, placebo-controlled trail, which is the gold standard for research.  The study lasted four years.  Some women were given low dose aspirin, some women were given low dose aspirin combined with low molecular weight heparin, and some women were given a placebo.  The doctors, patients, and nurses did not know which medications the women received.  The researchers found that neither aspirin, nor aspirin combined with low molecular weight heparin, improved live birth rate more than the placebo.

However, another study found that for certain women with recurrent miscarriages, low dose aspirin with low molecular weight heparin did improve pregnancy outcomes.  This study followed 156 women in India, 75 with Polycystic Ovarian Syndrome (PCOS) and 81 without PCOS.  All the woman in the study received intravaginal micronized progesterone twice daily.  The women with insulin resistant PCOS took metformin throughout their pregnancies.  The researchers found that the only group that benefited from the low dose aspirin and low molecular weight heparin were women with very high levels of homocysteine in their blood (classified as hyperhomocysteinemia).  Hyperhomocysteinemia was more prevalent in woman with PCOS.

One of my favorite sessions that I attended at the European Infertility Medicine Conference (ESHRE) answered the question of how long should you wait after a pregnancy loss before trying again.  To me, this is science at its best—answering a real life question faced by millions.  Couples are often counseled to wait 6 to 12 months before trying to conceive again after a miscarriage.  Scottish researchers looked back at 30, 937 women between 1981 and 2000 that conceived after a miscarriage.  They found that woman who conceived less than 6 months after a miscarriage were less likely to have another miscarriage, less likely to have an ectopic pregnancy, less likely to have a pre-term delivery, less likely to deliver by caesarean, and less likely to have a baby with low birth rate. The researchers concluded that there were no advantages to waiting to conceive after a miscarriage.

Image credit: Jessikaori

06/07/2010 | by Dawn Davenport | Categories: Blog, Infertility, Infertility Blog | 9 Comments

9 Responses to Miscarriage/Recurrent Pregnancy Loss

  1. Avatar Lois says:

    Just passing on this A blog with substance award: http://makingourfamilycomplete.blogspot.com/2010/07/we-won-blogging-with-substance-award.html You more than deserve it. Thanks for all the wonderful information you share with us. It is so valuable and much appreciated.

  2. Avatar Mistie Thompson says:

    Thank you so much for all the great information you shared from ESHRE. Our patients and followers on Facebook and Twitter really appreciated getting the latest information and study results from the conference!

    • Avatar Dawn says:

      Mistie, it’s my pleasure. it was a fun conference. I was like a kid in a candy store getting to interview all the great researchers. I know it sometimes seems slow, but real progress is being made in treating this disease.

  3. Avatar Amy Powers says:

    Thank you for all of this wonderful information!

  4. Avatar Infertiity Sucks says:

    We live abroad and information is hard to come by on miscarriages here and I really appreciate this blog on the research and especially the shows you’ve done on it as well. I know the doctor on your show was really encouraging about most people like me getting pregnant and I hang onto that thought all the time. thank you.

  5. Avatar Ina says:

    Thank you for all you do to help educate us and to let us know each day that we aren’t suffereing alone. Even though you adopted, you don’t make the rest of us feel like there is something wrong with us for not doing that. I really feel you compassion and that’s why look forward to reading your blog every week.

  6. Avatar dana says:

    After having my 4th miscarriage last month, I am taking you advice in your show and I’m going to go to a specialist. there has got to be a problem somewhere that can be fixed. If one more person tells me it is for the best, I will scream and probably attack them.

  7. Avatar Rebecca says:

    This is not science I know, as it is only a testimonial. But my Aunt had 4 misscarriages in a row without a successful term pregnancy when her doctor recommended low dose aspirin and with her next two pregnancies she carried her babies to term. With her they figured that she was throwing tiny clots that were depriving the placenta of blood flow and causing it to die and thus causing a misscarriage (always before 12 weeks, when the placenta is still relatively small). So while low dose aspirin may not work for everyone as the studies are showing, there may be a segment of the population that this is a solution for.

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